We found the SPARK!

SPARK: powerful tool for autonomous AI research in pathology and oncology

The results of our paradigm-shifting study to reasoning and multi-agentic AI have been published in Nature Medicine. This study introduces SPARK, an agentic framework for autonomous scientific discovery in cancer pathology that works without training across H&E slides, multiplexed imaging, five tumor types, and 18 patient cohorts. It generates explainable biological concepts, predicts biomarkers.

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Trost F, Zhang B, Aring I, Bauer M, Glamann L, Wessolly M, Johnson K, Göbel H, Lerbs T, Sangenne T, Herrmann P, Mairinger F, Kopp C, Michels S, Rasokat A, Heldwein M, Wagner S, Schömig-Markiefka B, Wolf J, Hartmann S, Wickenhauser C, Bychkov A, Klussmann JP, Quaas A, Buettner R, Tolkach Y. An agentic framework for autonomous scientific discovery in cancer pathology. Nat Med. 2026 Jun;32(6):2254-2266. doi: 10.1038/s41591-026-04357-y. Epub 2026 Apr 29. PMID: 42056496; PMCID: PMC13278948.